Episode 165. Regenerative Medicine using stem cells with Dr Jeffrey Gross

Written By Andrew Ford

As a background to this podcast, the field of regenerative medicine has been gaining significant attention with the objective of restoring damaged tissues using biological products and influencing age-related decay.

The use of pluripotent stem cells has been extensively studied, aiming to nurture their undifferentiated state into specific cell types that align with the target tissues requiring repair. Another promising avenue in regenerative medicine is the application of exosomes.

Exosomes are nano-sized biovesicles released by all nucleated cells into surrounding body fluids upon fusion of intracellular multivesicular bodies with the plasma membrane. These small vesicles, measuring between 40 and 160 nanometers, were first identified in the late 1980s. Initially, they were considered cellular waste with little or no effect on neighboring cells. However, recent insights have revealed their crucial role in intercellular communication.

Exosomes carry a complex cargo of proteins, lipids, and nucleic acids, enabling them to deliver essential biological messages to target cells. This process can reprogram recipient cells remotely from their release and plays a major role in immune response, signal transduction, and antigen presentation. The cargo of exosomes may significantly differ depending on the function of the originating cell type and its physiological state, including states of transformation, differentiation, stimulation, or stress.

A current line of study aims to determine whether active exosome cargo can offer prognostic information on diseases such as chronic inflammation, cardiovascular and renal disease, neurodegenerative disorders, lipid metabolic diseases, and tumors. Additionally, due to their non-immunogenic nature, exosomes are being explored for their potential in delivering biological therapeutics across various biological barriers, including the blood-brain barrier.

To learn more about regenerative medicine, stem cell therapies, and the emerging role of exosomes, we welcome Dr. Jeffrey Gross. Dr. Gross is a leading expert in regenerative medicine, specializing in the application of stem cells and exosomes to support tissue repair and combat age-related degeneration. In this episode, he shares his insights on how these innovative therapies are shaping the future of medicine and what we can expect in the years to come.

References:

Dr. Jeffrey Gross - [Insert Contact Information or Website]

National Institute of Health: www.nih.gov

WebMD: www.webmd.com

Meldolesi J. Exosomes and Their Role in Tumor Progression. Cell Mol Life Sci. 2018;75(8):1339-1350.

Thery C, Witwer KW, Aikawa E, et al. Minimal Information for Studies of Extracellular Vesicles 2018 (MISEV2018). J Extracell Vesicles. 2018;7(1):1535750.

Andrew Ford
Marketing expert Andrew Ford, the founder of Social Star, has discovered the secret of ‘Powerful Branding’. With a fire for unleashing people’s inner brand and developing business models to generate profit from an individual’s passions, Andrew leverages ground-breaking digital and social media marketing techniques to create digital strategies for clients to attract maximum opportunities. Having established a strong name for himself in the field, Andrew blends traditional business techniques with now-necessary tools for entrepreneurs to achieve scale, quality, and influence in their niche. Andrew’s comprehensive business background and qualifications consist of a Bachelor of Business (Marketing) (RMIT 2003), a Graduate Certificate in Management (MBA Executive Program, University of Sydney 2005), and a Masters of Entrepreneurship and Innovation (Swinburne University 2011). Continually on the cutting edge of his own education, Andrew has tested his marketing theories in forums such as the BCG Business Strategy Competition, which he won in 2005 against all Victorian MBA schools, and the Venture Cup Business Plan Competition (Swinburne University 2003), which he won in the Masters category. With experience working at Hewlett-Packard, Sensis (Telstra) and IBM, Andrew also has mentored dozens of junior staffs to help them achieve their professional goals. Meeting and influencing high-profile public figures helped Andrew to realise just how many professionals require more understanding and control of their public brands or appearance, and need help with the skills to use the many amazing free tools at their disposal to generate success. At Social Star, Andrew consults with clients to uncover their personal brand – both where it is today and where it can be tomorrow – and refine and define how that should be displayed in social media in order to attract their perfect target audience. Andrew mentors his clients to rapidly grow their business’ audiences, resulting in larger potential client bases and higher revenue. Applying formulas that integrate over twenty years of Andrew’s business experience and fifteen years of formal business education, Social Star specialises in building clarity and velocity for clients’ brands using the ‘Understand, Build and Leverage’ methodology. ‘Having a Personal Business enables people to have an authentic, congruent connection with their valued clients and partners, using their brand as the bridge,’ says Andrew. ‘I’m highly driven to work with the new breed of entrepreneurs and small business owners – people who have a passion for making the world a better place. Traditional business models are stepping aside as people follow their innermost dreams and my role is to see them operate within their values while creating wealth. Some people think you have to sacrifice what you love to be successful in your business, yet it is actually the opposite. Follow your passion and success will come.’ Lecturing at Swinburne University from 2009 to 2011 on brand dynamics and digital marketing, presenting at numerous conferences, and consulting to hundreds of clients, Andrew has seen his philosophy work that if you follow your unique path, based on your skills, experience, values and goals, you will automatically attract the opportunities you desire and achieve the success you deserve. Living his mantra, Andrew has created a successful business and attracts high-profile clients including musicians, athletes, authors, models, entrepreneurs, professionals and small business owners, helping them find their ‘why’ in their business and fulfilment in their lives. Business for Andrew is more than work, it’s personal. Running a personal business means that he is able to fulfil all of his values rather than separating his life from work. It supports his two boys while providing social opportunities, educational development, fitness opportunities, spiritual fulfilment and many valuable friendships. Social Star has now become the vehicle for Andrew to crystallise his mission in the world, to help people love what they do, supporting his ‘why’, that if more people loved what they did, the world would be a better place.
http://www.andrewford.com.au/
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Episode 164. Vascular Fistulas - The Door to Haemodialysis with Dr Ming Yii